An ulcer is a local defect, or excavation of the surface of an organ or tissue, which is produced by the sloughing of inflammatory necrotic tissue. The term "peptic ulcer" refers to a group of ulcerative disorders of the upper GIT, which appears to have in common, the participation of acid pepsin in their pathogenesis. A peptic ulcer probably results [...]
In this article we will discuss about:- 1. Principle of Langendorff Heart System 2. Langendorff System-Technical Information 3. Preparation 4. Applications. In 1895, Langendorff described studies on isolated surviving mammalian hearts, using mainly cats as donors. Since then, the method has been improved and is now used for studies on guinea-pig, rabbit or rat hearts. Principle of Langendorff Heart System: [...]
In this article we will discuss about the selection of animal model for cardiovascular screening. Primates: A wide variety of animal species and strains have been used as models of CVD, with variable degrees of success. As seen in humans, an ideal model – small and economical, yet large enough to permit desired experimental procedures – will precisely mimic CVD. [...]