In this article we will discuss about:- 1. Principle of Langendorff Heart System 2. Langendorff System-Technical Information 3. Preparation 4. Applications. In 1895, Langendorff described studies on isolated surviving mammalian hearts, using mainly cats as donors. Since then, the method has been improved and is now used for studies on guinea-pig, rabbit or rat hearts. Principle of Langendorff Heart System: [...]
In this article we will discuss about the selection of animal model for cardiovascular screening. Primates: A wide variety of animal species and strains have been used as models of CVD, with variable degrees of success. As seen in humans, an ideal model – small and economical, yet large enough to permit desired experimental procedures – will precisely mimic CVD. [...]
Toxicokinetic studies (generation of pharmacokinetic data either as an integral component of non-clinical toxicity studies or in specially designed studies) should be conducted to assess the systemic exposure achieved in animals and its relationship to dose levels and duration of treatment. Toxicity testing is of paramount importance while screening drugs. From the 1950s to the 1960s thalidomide was sold in [...]